Surprisingly, this analysis revealed a highly concordant regulation of individual miRNAs in AS and HTX (r2 = 0.79, slope = 0.9±0.07; n = 40, Figure 3).
A highly concordant classification could be constructed with a published gene set (Sorlie's intrinsic gene set, concordance 90%).
Quantitative RT-PCR analysis revealed a highly concordant expression change in selected genes with data obtained by microarrays.
Using publicly available RNA-seq data, we show that ACE predictions confirm earlier results regarding the quantitative effects of nonsense-mediated decay, and we show that predicted loss-of-function events are highly concordant with patterns of intolerance to mutations across the human population.
While our universal 56-gene model showed consistent prediction performance on the three independent test sets, we further investigated whether these predictions could be improved by using biomarkers that preserved highly concordant expression patterns between different cell types of leukocytes.
Figure 2 shows a concordant pattern between parametric PTF, PTI and LGE CMR images in a patient with ischaemic cardiomyopathy after an anterior myocardial infarction.
The estimated CNV genotype (Additional file 4 (A)) was highly concordant with the validated genotype (Additional file 4 (B)).
The intensity of each antibody staining at 4 to 28 wk showed a concordant pattern with the RNA expression profile.
EF1a did not show evidence of strong selection, and in specific aspects, EF1a showed a concordant pattern with the COI data.
Applying the COXEN algorithm, we identified 48, 6, and 25 genes (among these 56 genes) that preserved highly concordant gene expression patterns between patient sets FH1 and FH2, FH1 and FH3, or FH1 and ATHERO1, respectively, with a Pearson correlation association p-value < 0.001 (Table 2).
