Other antiepileptics with lesser evidence of efficacy, but a higher tolerability profile can be alternatively used, such as gabapentin and, in some cases, pregabalin [401].
This recommendation was largely based on the high tolerability of BoNT-A and the safety concerns related to opioids, despite the fact that effectiveness and the bulk of evidence favoring opioids, particularly oxycodone and morphine, is far more robust [10].
Thus, tolerance to MTX therapy may be used as a surrogate measure for potential high tolerability of anti-TNF treatments in clinical practice.
The high tolerability of this formulation during years 1 and 2 was maintained during year 3; 5.5% of patients withdrew from treatment because of adverse events in the final year.
The high tolerability of PARP1 for small molecules appended to 2H-phthalazin-1-one resulted in a number of high affinity binders in our small molecule library, the best representative of which, [124/131I]-I2-PARPi, was tested as a PET and SPECT tracer.
Attitudes towards "defensive" medicine could be a key determinant, so that some doctors may consider this prescribing behaviour safer, also considering the high tolerability of proton pump inhibitors.
The rationale for the combination of gemcitabine plus mitoxantrone was the therapeutic efficacy, the low systemic toxicity and the high tolerability of both drugs.
Cancer immunotherapy using protein-based therapeutics such as EGF-MAP will require repetitive administration, and thus the relatively high tolerability of CFPs make them superior to classical ITs.
Considering the high tolerability of ivermectin, it would be probably worth treating high – risk patients irrespective of the result of the screening test, in order to avoid the potential consequences of a possible false negative result.
These findings suggest that PregVit® may confer an advantage to women suffering from NVP due to both higher tolerability because of lower iron content and a smaller tablet size.
