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They also conclude that a higher replication factor would create an unbearable communication overhead.
However, a higher replication factor in the reduce step (VCS-30R3) improves the overall application turnaround time.
The size and the number of plaques were slightly higher in L929 than in Vero cells, but this difference was strictly correlated with a higher replication of bacteria within the former (not shown).
A likely much stronger selection force for uniparental inheritance will arise if an organelle with a higher replication speed carries a genotype that is incompatible with or maladaptive to the host nucleus.
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Setting high mold temperatures for injection-molding plastics facilitates favorable flow conditions for filling cavities with melted materials and provides an esthetically pleasing surface as well as a high replication rate of high-quality products; however, the cooling times are typically prolonged.
This effect may be due to a high replication rate in epithelial cells as it has been shown for a highly virulent PR8 variant [47].
Furthermore, a high replication rate and the lack of proofreading activity of the viral RNA-dependent RNA polymerase generate a dynamic mosaic of closely related variants, usually referred to as quasispecies, within an infected individual.
Previous experimental studies demonstrated that oropharyngeally excreted HPAIV originated from lung and air sacs [12], implicating a high replication rate of the virus and thus a possible functional impairment in organs important for long-distance flight and migration.
We found that Ae. aegypti as well as Ae. albopictus ensured a high replication of the virus which underwent an efficient dissemination as detectable in the salivary glands at day 2 post-infection (pi).
Thus, modulation of fatty acid catabolism could be detrimental to virus formation and could be a cellular mechanism to both produce energy and fight against a high replication of DENV-2.
Genetic diversity in influenza virus results from a high replication error rate associated with low-fidelity RNA polymerase, and the reshuffling (or reassortment) of gene segments among co-infecting strains [1] [3].
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