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"Companies over the last 20 years have found a higher necessity to leverage balance sheets," Mr. Rao said.
Regularly transfused patients reported a higher necessity of DFO chelation.
In general creatinine-based equations resulted in a lower eGFR-estimation and in a higher necessity of drug dose adjustment than Cystatin C-based equations.
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It could also indicate that children who received lower doses did not perceive a high necessity for MTX therapy, owing to their low disease activity, and therefore were less likely to take their medication consistently.
Nevertheless, no established tissue molecular markers for NPC have been used so far in clinical practice; thus, the identification of novel prognostic and predictive biomarkers for NPC is a high necessity [ 32].
Conducting a cross-sectional study, the authors found that higher necessity scores correlate with higher reported adherence, whereas higher concerns correlate with lower reported adherence [ 36].
The paper proposes a methodology and design rules for organisational structures facing higher necessity of rapidly reconfigure themselves to cope with unpredictable situations new markets, new products, changing mix of production, problems in production process or flows etc.
Higher necessity scores indicate higher beliefs that transfusion/chelation is necessary for their health.
Higher numbers of clinical complications were associated with higher necessity of DFO and higher Sensitive Soma score.
8 Multiple studies have demonstrated that better adherence is associated with higher necessity beliefs and fewer concerns about treatment.
In general, creatinine-based equations resulted in lower eGFR-estimation and in higher necessity of drug dose adjustment than cystatin C-based equations.
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