The phrase "a higher mutation prevalence" is correct and usable in written English.
It can be used in contexts discussing genetics, epidemiology, or any field where mutation rates are relevant.
Example: "In this study, we observed a higher mutation prevalence among the affected population compared to the control group."
Alternatives: "an increased mutation rate" or "a greater frequency of mutations".
Titin (TTN) was also selected as a non-cancer gene because it has a high mutation prevalence probably due to its massive size.
We found that while the PI3K_p85B domain, which is responsible for binding the PI3K p85 subunit to form a heterodimer [ 29], was identified as a significant domain peak in both cancer types, the domain only had a high mutation prevalence (threshold of 0.04) in the colon cancer set.
Other ASXL1-related abstracts that were presented at ASH 2010 included c.1934dupG p.Gly646TrpfsX12 as a true mutation and reported much higher mutation prevalence in PMF and post-MDS/CMML AML.
PIK3CA contains a total of five domains, so we compared the domain peaks identified by our method to the domains identified with high mutation prevalence, a measure commonly applied to identify genes mutated in a high percentage of patients.
Seven significantly mutated genes, including four reported (APC, TP53, KRAS and SMAD4) and three novel recurrently mutated genes (CDH10, FAT4 and DOCK2), exhibited high mutation prevalence (6 14% for novel cancer genes) and higher-than-expected number of non-silent mutations in our CRC cohort.
Three novel recurrently mutated genes, namely CDH10, FAT4 and DOCK2, were identified to exhibit high mutation prevalence in the Asian CRC cohort.
We also did not find significant mutation frequency or high mutation prevalence in the PI3K_rdb, RAS-binding domain, or in the PI3K_C2 domain, which contains signals for the cellular localization of the PIK3CA protein [ 30].
Besides genes of 5q22.2 and 18q21.1-q21.2 described above, we also investigated genes with high mutation prevalence (i.e., P53, KRAS, and PIK3CA), as well as those with intermediate-low mutation prevalence (i.e., SMAD2 and SMAD3) in human CRC [ 46].
Due to extensive exposure to carcinogens, small cell lung cancer (tobacco) and malignant melanoma (ultraviolet light) show the highest somatic mutation prevalence (over 100/Megabase (Mb)).
The weakened association evident since 1996 may reflect a higher overall prevalence of mutation with a higher prevalence among those unexposed to prophylaxis, or it may reflect that fewer HIV-infected patients take prophylactic drugs because of HAART.
