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Due to the 223Ra (daughter) affinity to bone, patients with a high risk of developing bone metastasis might be an intriguing application [22, 23].
Such an application of the CTX bone resorption markers may be especially relevant for breast cancer patients, who have a high risk of developing bone metastases.
With advances in molecular biomarkers that refine and improve risk stratification in patients, those with a high risk of developing bone metastases may benefit from adjuvant or prophylactic treatment with targeted therapeutics, as long as the cytotoxicity is supportive of long term chronic administration.
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Among all the 380 patients, 308 have been classified as low-risk of bone metastases, and 72 as high-risk of bone metastases.
11 On February 8 , 2012 the FDA Oncologic Drugs Advisory Committee voted 12 to 1 against the approval of denosumab for the treatment of men with castration-resistant prostate cancer who are at high risk of developing bone metastases.
Comparing with the "no-AKI group", those in "recovery-AKI group" had 6.5 folds higher risk of developing bone fracture in a mean follow-up period of 3.9 years.
To identify molecular markers and molecular subtypes in breast carcinoma that predict patients at higher risk of developing bone, brain, and visceral metastasis.
Roberts' disease involves damaged bone marrow, which carries a high risk of developing into leukemia.
Remarkably, the presence of a single DTC in the bone marrow of a patient with cancer accurately predicts a high risk of developing metastases.
Those with the condition are at a high risk of developing colon cancer.
Lupus patients have a high risk of developing cardiovascular disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com