The phrase "a high quality whole" is correct and usable in written English.
It can be used to describe something that is both complete and of superior quality, often in contexts related to products, services, or experiences.
Example: "The restaurant prides itself on providing a high quality whole, from the ingredients to the dining experience."
Alternatives: "a complete high-quality product" or "an excellent overall experience".
While we focused on a single QTL region, other QTL regions of importance could be similarly sequenced allowing for biological discovery to take place before a high quality whole-genome assembly is completed.
A number of canine genomics resources have been developed to facilitate genotype-phenotype inferences, including a high-quality whole genome sequence and a dense catalog of SNPs discovered in a wide variety of breeds [ 1- 3].
During the ensuing years, rapid progress has been made in developing research tools for this small annual grass, including efficient transformation methods [ 2- 4]; a high-quality whole genome sequence [ 5]; large germplasm collections [ 4, 6- 8]; T-DNA mutant resources [ 9, 10]; and more.
To implement this strategy, we focus on the dog genome as an example, as it offers a high-quality whole-genome Sanger sequences (WGS) and assembly [ 36].
Development of such tools is facilitated by a high-quality whole-genome shotgun assembly [ 2] and the organization of most of the resulting contigs into chromosomes via a SNP-based recombination map [ 6].
Genome comparison between the genomic sequence of strain 8081 [ 12] and a high-quality whole-genome sequence of strain WA-314, presented in this study, allowed the identification of putative virulence factors which may account for the different in vivo phenotypic behavior of these two 1B/O:8 strains.
Sequence capture methodology continues to be an effective tool for acquiring high quality whole genome sequence data [ 2, 38, 39], especially when cultured isolate gDNA of high concentration and genome copy number is used as a template, as in the present study.
We developed MethylExtract, a user friendly tool to: i) generate high quality, whole genome methylation maps and ii) detect sequence variation within the same sample preparation.
There are two possible ways to update the currently used Y chromosomal phylogenetic tree: first, making Tabula rasa of the current phylogenetic tree and obtaining a new phylogeny based on only the high quality whole sequenced Y-chromosomes, or secondly, controlling the current phylogeny and including new validated Y-SNPs based on whole sequenced Y-chromosomes.
Given these findings, the generation of high quality whole genome methylation maps at a single cytosine resolution is an important step towards the understanding of how DNA methylation is involved in the regulation of gene expression or the generation of a pathologic phenotype.
