After removing some of the trials and data based on more rigorous standards for a high quality meta-analysis, a significant benefit of the intervention could no longer be shown.
In a high quality meta-analysis of nine observational studies (2775 patients), 26 CYP2C9*2 and CYP2C9*3 alleles were associated with a requirement for a lower warfarin dose and an increased risk of bleeding.
We recognise the considerable resources and international cooperation required to perform a meta-analysis based on individual patient data and will build on already existing relationships 31 to produce a high quality meta-analysis.
A high-quality meta-analysis in 2010 did not find evidence of RRS teams reducing hospital mortality in adults [ 17].
When a high-quality meta-analysis was available, it served as the basis for the review, and was updated with results of more recent studies when available.
A high-quality meta-analysis [ 34] and a consensus statement [ 33] suggested that TCD is a useful tool to rule in vasospasm in the MCA, with high specificity and positive predictive value of 99%and97%7%, respectively.
A recent high quality meta-analysis of RCTs of interventions of diet and physical activity, alone or in combination, which included studies where women were obese, overweight and normal weight, found an overall 1.42 kg difference between intervention and control participants in GWG (in favour of the intervention group) [ 33].
We based the effectiveness of angiotensin blockade by conducting a focused literature search that identified relevant high quality meta-analyses and randomised trials in people with chronic kidney disease.
The assessments for each study are reported in Table 1, with the quality ratings being the following: 1++: High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias.
High quality meta-ethnographies [ 5] have informed recent clinical guidelines [ 7].
In general though, our analyses were guided by estimates of effectiveness from high quality meta-analyses.
