The phrase "a high population frequency" is correct and usable in written English.
It can be used in contexts related to statistics, biology, or demographics to describe how often a particular trait or characteristic appears within a population.
Example: "In this study, we observed a high population frequency of the genetic marker among the participants."
Alternatives: "a high occurrence rate" or "a high prevalence rate".
This case is unusual, in that a SNP with a massive effect on the odds ratio nevertheless showed a high population frequency for the disease-predisposing base.
Another approach to infer evidence of past selection is the "Extended Haplotype Homozygosity" (EHH) test [ 11] which identifies regions with an unusually long range of haplotype and a high population frequency.
Because estrogen exposure is a known factor in the etiology of breast tumors, and because the SULT1A1*2 allele is a low-activity allele with a high population frequency, we hypothesized that this allele might represent an important modifier of breast tumor characteristics.
Therefore, the ethnic characteristic of the German population might contribute to the significant associations observed in the study, because the detection of potential influences of genetic parameters on disease course and susceptibility is facilitated by a higher population frequency.
A signature of positive selection is indicated by unusually long haplotypes and high population frequency [ 14].
Therefore, disease gene variation taking the form of cis-acting eQTLs may have a narrower allelic spectrum toward high population frequencies, as predicted by the common diseases/common variant (CDCV) model that genetic risk of common diseases is often conferred by alleles having relatively high frequencies [32].
This is because such alleles evolve into higher population frequencies for a given effect size, relative to alleles experiencing equally strong purifying selection in both sexes.
A neutral mutation will take many generations until the mutated allele reaches a high or low population frequency.
Genetic variants were selected as having a described population frequency higher than 10%.
These include: the apportionment of diversity within and between populations (Fig. 3); an SFS that provides a consistently higher signal of higher TE population frequencies in A. thaliana at both species-wide (Fig. 4) and population scales; and apparent differences in selection coefficients (Fig. 5).
Arguments in favor of this hypothesis are that sites of both elements, found at a low frequency in the original populations, are now at a high frequency in populations resulting from the two colonisations.
