The mild neurocognitive disturbances seen in five patients were investigated and did not suggest RPLS at this stage, but led to a higher level of observation for this toxicity in the phase II study.
To the contrary, by referring data to a higher level of observation, that is, when the cell-microenvironment interaction or the tissue levels are kept in consideration, conflicting results end up as such, and paradoxes may likely find a compelling explanation.
Our observations point to a high level of conservation of SIRT3 as a mitochondrial protein in mice and human and indicate that several previous studies, which addressed mouse Sirt3 function, need to be re-evaluated.
Repeat analysis done using different statistical methods did lead to more gene overlap, but the final conclusion was that gene array studies of stem cells are influenced by cell purity and can be contaminated by a high level of non-specific observations in the data.
The observation that the minority partner in many minority majority couples has a high level of education, and the observation that second- and later-generation members of ethnic minorities have higher rates of forming mixed ethnic unions with a member of the majority group than foreign-born immigrants seem to support integration theories (Hwang et al. 1997; Muttarak 2003).
Despite a high level of client satisfaction, direct observations indicated poor quality of ANC services: just over half of ANC clients received any health education; in addition, ANC attendance did not influence the use of other maternal health care, such as facility-based delivery [ 25].
For example, the low sampling rate and high level of observation noise make it impossible to detect relatively high vibration bridge frequencies (Meng 2002; Meng et al. 2007; Breuer et al. 2015; Górski, 2017).
The inclusion of 627 patients with >5 years of observation, with some patients having received up to 17 rituximab courses over 9.5 years of observation, affords a high level of confidence in the data and increases the probability of detecting common and infrequent safety risks compared with previous studies.
Ethnography allows for a high level of congruence between concepts and observations as it involves prolonged participation in the social life of the group over a period of time and description of things witnesed first-hand (Denscombe 2013).
