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43 There was evidence of improved accessibility, but services were heterogeneous, and there was a high level of missing data.
The remaining 28S sequences are distributed over the whole tree and provided good resolution of the backbone, which is why we decided to include them despite a high level of missing data.
Stringent filtering criteria (see Materials and methods and Table 1) were applied to identify and remove individuals and SNPs with a high level of missing data and/or Mendelian errors.
There was a high level of missing data for % predicted FEV1 at baseline and when it was excluded as a covariate from this analysis, the known-groups validity F-statistic was 279.49 (p < 0.001) for mMRC scores and 83.90 (p < 0.001) for the BDI scores (Table 1).
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This led to a higher level of missing data in our study.
The high level of missing data for some variables is also a major limitation.
Additionally, the high level of missing data may itself be of significance.
We were unable to adjust for SES while calculating the overall survival owing to the high level of missing data at the beginning of the NLCA.
Therefore, multiple imputation was used to more accurately account for the high level of missing data for all analyses involving these two variables (14).
Interviewer 'D' had a slightly higher level of missing data for the baseline interview; all other interviewers had very little missing data.
We conclude that high levels of missing data in dense marker sets is not a major obstacle for genomic selection, even when marker order is not known.
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