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In consequence, the often-quoted hepatotoxicity and nephrotoxicity of MCs are the result of a hepatic first-pass and subsequent renal elimination effect in organs having a high level of functionally expressed OATPs/Oatps capable of MC transport.
Direct sequencing of the putative MH IIα peptide-binding region in a population sample of 101 individuals identified a high level of functionally important genetic variation, with 18 alleles observed in the 246 bp region, including 25 substitutions at 24 polymorphic nucleotide sites.
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We have shown here that even in the presence of this genome wide reduction in variation, Timor zebra finches have maintained a high level of diversity in the functionally important MHC (Fig. 2 and Additional file 3).
Thus, it is a challenge for society to maintain a high level of physical activity and stay functionally fit to achieve healthy aging.
Notably, mitochondria in vivo behave as a network of functionally coupled oscillators, which maintain a high level of coordination throughout the tissue via the activity of gap junctions.
The level of sequence divergence amongst orthologous CPRs, for example, is often low outside of the conserved chitin-binding domain despite a high level of divergence among paralogues, indicating that these regions are functionally constrained.
Of the family of 12 annotated GGPPS genes in Arabidopsis [ 41], only GGPPS1 (At4g36810; r = 0.74, e-value <1-35), that encodes a functionally active and plastid localized enzyme [ 43], displays a high level of expression correlation.
Nanzhao attained a high level of culture.
He has a high level of energy".
This creates a high level of anticipation.
That suggests a high level of engagement.
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