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The phrase "a high fraction of" is correct and usable in written English.
It can be used when discussing a significant portion or percentage of a whole in various contexts, such as statistics or research findings.
Example: "A high fraction of the participants reported feeling satisfied with the program."
Alternatives: "a large percentage of" or "a significant portion of".
Exact(60)
A high fraction of the Indus Basin is covered by snowfields and glaciers.
Based on a time-course dataset, we obtain a high fraction of time-delayed correlations.
"A random knockout of even a high fraction of nodes will not damage the network," Dr. Barabasi said.
Davydov, E. V. et al. Identifying a high fraction of the human genome to be under selective constraint using GERP++.
A high fraction of aerobic anoxygenic phototrophic bacteria in metagenomes from a coastal bay (Arraial do Cabo Brazil).
Davydov, E. V. et al. Identifying a high fraction of the human genome to be under selective constraint using GERP.
The heterotrophic microalga Crypthecodinium cohnii accumulates lipids with a high fraction of docosahexaenoic acid (DHA).
Is it wise to have such a high fraction of my savings in a relatively illiquid asset?
Although Herceptin has significantly improved the treatment of HER2-positive tumors, drug resistance remains an obstacle in a high fraction of patients.
All datasets exhibited a good read quality (Phred score > 20) and a high fraction of read alignment to the reference genome (alignment score ≥ 93%) using HISAT.
However, at much higher reduction levels, micrographs show a high fraction of Cu-type shear bands.
More suggestions(16)
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and a high fraction of patients
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com