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A high fish intake was found to be associated with a decreased risk of colorectal cancer (Norat et al 2005).
The measurement of the concentration of T-Hg in blood is generally a good surrogate for the concentration of MeHg in blood in human populations with a high fish consumption [ 12, 16].
Although MeHg exposure originates from contaminated seafood and freshwater fish, a high fish intake is also thought to provide protective effects against coronary heart disease (Burr et al. 1989; Mozaffarian and Rimm 2006; Oomen et al. 2000).
Higher maternal compared to infant RBC-DHA contents were previously noted after daily supplementation of pregnant women from 20 weeks of gestation until delivery with a high fish oil supplement containing 2.24 g DHA and 1.12 g EPA [ 47].
For evaluation of Hg distribution in hair, and blood to hair ratio, we also used data previously collected in a study of women with a high fish intake (N = 145, 20 50 years of age; [ 31]).
We recently reported a detailed time course study of the individual and combined chemopreventive effects of Tamoxifen and a high fish oil diet on multiple histologic parameters of MNU-induced mammary carcinogenesis [ 13].
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Applying the criteria of Cappuzzo et al in our study revealed a high FISH-positive rate of NSCLC in cytological specimens (63.6%) that contrasted with a low rate in matched biopsy specimens (24.2%).
Instead of the omega-3 PUFAs, we found that a higher fish consumption was associated with lower prevalence of depressive episodes in the men but not in the women.
A higher fish intake generally corresponded with a higher consumption of fruit and vegetables and meat for both genders, and with a higher physical activity level.
The extant literature suggests that risk of mortality is reduced in patients with a higher fish intake and those with higher serum omega-3 fatty acid levels.
A study of over 90 000 subjects in Japan showed a significant, dose-dependent decrease in risk of development of hepatocellular carcinoma in people with a higher fish and n-3 PUFA intake, even in a high-risk group after adjustment for additional risk factors (Sawada et al, 2012).
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