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A high complete remission rate was also seen in another study [ 63].
This clinical trial showed a high, complete antiemetic response rate with a single dose of palonosetron, irrespective of patient age.
The VIP regimen was chosen as the standard arm in the German randomised trial since VIP had shown a high complete remission rate, no pulmonary toxicity and a very low relapse rate in a preceding phase II trial in patients with seminoma (Clemm et al, 1993).
Recently, many studies on locoregionally advanced SCCHN have been focusing on neoadjuvant chemotherapy (NAC) with a high complete response (CR) rate followed by definitive radiotherapy, or concurrent chemoradiotherapy showing to improve the survival rate and to preserve functions and organs (Pignon et al, 2000; Monnerat et al, 2002; Forastiere et al, 2003; Haddad et al, 2003).
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Comparisons of percutaneous cryotherapy and RF have shown a higher complete ablation rate with RF [ 18].
Other studies reported a higher complete pathological response rate ranging from 8%too 10.5%, using similar chemotherapy scheme [ 16, 18].
The patients received rituximab appeared to have a higher complete remission rate than those who did not (70.4% vs 44.4%).
In acute myelogenous leukemia, increased miR181a expression was significantly associated with a higher complete remission rate of the patients [ 20].
The authors also observed a trend toward a higher complete response rate in patients treated with higher doses of IL-12 [ 154].
A CLcrea ⩽85 ml min−1 was associated with a higher complete remission rate and better survival, which was independent of age, PS, DIMTX, IRMTX, and other therapeutic variables.
As reported in Table 4, a slow CLcrea (⩽85 ml min−1) was significantly and independently associated with a higher complete remission rate.
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