Such variation could be explained by a hierarchy of preferential expression of different alleles, as is seen for the X-linked Xce locus [37].
Given the background exposed above, a first question concerns the systematic exploration of the effect of a hierarchy of gene expression times on cell-fate specification during early flower development.
In developing embryos such as those of Drosophila melanogaster, a hierarchy of precise protein expression guides the growth of the embryo in space and time at a large range of temperatures.
The different probabilities of gene activation by these routes generate a hierarchy of antigen-type expression during infections, contributing to the progressive waves of parasitemia characteristic of trypanosome infection (Gjini et al., 2010; Lythgoe et al., 2007).
Analysis of gene correlations across all data sets, independent of "cell of origin" class, demonstrates a consistent association with a hierarchy of immune-regulatory gene expression that places IDO1, LAG3 and FGL2 ahead of PD1-ligands CD274 and PDCD1LG2.
Unbiased analysis of gene expression correlations moreover suggests a hierarchy of IFN-associated immune modulatory gene expression with LAG3, IDO1 and FGL2 as key elements in this context.
Tumor growth is a tissue-level quantity is regulated by a hierarchy of steps starting with Shh expression and hedgehog activation.
Thus, along with the constraints imposed by the GRN, a hierarchy of decay times of gene expression may define alternative routes to cell fates [ 21, 33].
In the first paragraph of the Results section, the expression "a hierarchy of binding affinities": what does this mean in terms of the model and how is this hierarchy calculated?
Following identification of pro-inflammatory gene and protein expression in atherosusceptible endothelium in vivo [ 4], many in vitro studies identified a hierarchy of regulation of gene and protein expression in cultured endothelial cells in response to recapitulated arterial flows (reviews [ 10, 11]).
