Each library was constructed using a separate heterogeneous source of genomic DNA.
Besides, we admit that the use of this sample to represent the North African population constitutes a simplification of the heterogeneous source of African influences that have affected the Spanish populations.
All these contributions confirmed that human and animal reproductive tissues represent a very interesting and heterogeneous source of stem cells: from ovarian and testicular stem cells to embryonic (J. M. Campbell et al.; S.-J.Park et al)., trophoblast (M. Weber et al)., endometrial decidual (E. Rossignoli et al)., and umbilical cord stem cells, and induced pluripotent stem (iPS) cells.
A possible limitation of our study is the heterogeneous source of the MIC data.
We used the DAVID knowledgebase [12] for functional enrichment analysis as it provided a practical mean to gain access to a wide range of heterogeneous sources of gene annotation (152,543 annotation terms were used for human, 105,207 for mouse and 39,787 for rat).
The assumption of a Gaussian White Noise represents an approximation of multiple heterogeneous sources of noise that might occur on the molecular level.
The database has a flexible structure for management of data from heterogeneous sources of systems microscopy experimental outputs generated by a variety of protocols and technologies and can be queried by gene, reagent, gene attribute, study keywords, phenotype or ontology terms.
Succeeding in this task requires to carefully plan and organize the whole process of data analysis taking into account the particularities of the social and economic analyses, which include the wide variety of heterogeneous sources of information and a strict governance policy.
The method presented in this paper is part of a framework named CRAVELA which purports to be able to draw from heterogeneous sources of data and to offer an evidence-based tool to estimate the likelihood that a given set of precursor candidates are indeed pre-miRNAs.
While the wealth of information in these datasets presents an opportunity to leverage these for finding novel drug targets, it remains a challenge to systematically integrate all these highly heterogeneous sources of information to identify novel anti-cancer drug targets.
