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During 16 months, adults with a hematological disorder presenting with febrile neutropenia were enrolled in the study.
These observations suggest that individuals without overt features of a hematological disorder may harbor hemopoietic cell clones carrying leukemia-associated mutations.
Even with the adequate antimalaria therapy, the patient's condition evolved to an acute renal failure requiring hemodialysis, acute respiratory distress syndrome, septic shock, and a hematological disorder, forming a multiple organ dysfunction syndrome.
Similar(57)
Patients aged ≥18 years with newly diagnosed AML including de-novo AML and secondary AML after a preceding hematological disorder could be included.
Although CD56+ monocytes were found in 2001 in patients with Down syndrome with or without an additional hematological disorder [ 4], Sconocchia et al. first described CD56+ monocytes in the peripheral blood of healthy controls in detail in 2005 [ 2].
Multiple myeloma (MM) is an incurable hematological disorder in which malignant plasma cells accumulate in the bone marrow and is primarily distinguished from other premalignant plasma cell disorders, such as monoclonal gammopathy of unknown significance or smoldering MM, by the presence of end-organ damage as defined by the CRAB criteria: hypercalcemia, renal impairment, anemia and bone disease.
There were four patients with AML who were under 65 years and were considered not eligible for intensive induction therapy as they were diagnosed with an antecedent hematological disorder and in addition had adverse risk cytogenetics (n=2) or severe comorbidities (n=2).
Although the between-group prevalence of causative pathogens was similar, it was noted in liposomal amphotericin B-treated subjects that Candida krusei was isolated at baseline more frequently in non-ICU subjects (including three patients who had an underlying hematological disorder) compared with ICU subjects; nine isolates versus one isolate, respectively.
Excluded were sick or febrile children and those with a diagnosis of a chronic disease or hematological disorder.
In the subgroup of patients in whom TIs were diagnosed after the diagnoses of the primary hematological disease, the diagnoses of TIs were made at a median time of 15 months after the diagnoses of the primary hematological disorder.
Hence, oxygen transport gene deregulation can induce hematological disorder including erythrocytosis.
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