MDD patients are believed to express a heightened responsiveness to negative emotional stimuli and a reduced detection of positive affect [ 66, 67], which is explained by hyperactivity of the affective neurocircuitry, including the amygdala [ 68].
On the other hand, the fact that caloric restriction, independent of weight loss, improves glycemic control (13, 14) may suggest a heightened responsiveness of this risk factor to caloric imbalance and weight changes.
Using detection or discrimination measures or stimuli reported to trigger migraine (striped patterns or flickering lights) one finds differences between people with and without migraine, which is attributed to abnormal cortical processing in migraine, described by hyper- or hypoexcitability, heightened responsiveness, a lack of habituation and/or a lack of intra-cortical inhibition [50], [51].
Our findings underline the prevalence of pain and temperature symptoms across the FTLD spectrum and suggest a syndromic preponderance characterized by blunted versus heightened responsiveness to pain and temperature signals in behavioural variant FTD and semantic dementia, respectively.
The present data showing increased levels of both M1- and M2-like muscarinic receptor binding sites and heightened responsiveness to oxotremorine further suggest a role for muscarinic cholinergic neurotransmission in some behavioral impairment reported in this animal model, and add support to the functional relevance of cholinergic neurotransmission in schizophrenia.
This heightened responsiveness to the endogenous ER ligand perhaps also supports a role for ERβ subtypes in the generation of the estrogenic response.
This heightened responsiveness allows the liquid metal to be deformed at rates exceeding 120 mm/s, greater than an order of magnitude faster than existing techniques for electrical deformation.
Since two of four cell lines exhibiting heightened responsiveness to CD95-mediated signals following fractionated irradiation express mutant p53 and displayed little or no up-regulation of CD95, enhanced responsiveness did not correlate with p53 status and CD95 up-regulation.
While altered temperature responsiveness was more common than altered pain responsiveness across syndromes, blunted responsiveness to pain and temperature was particularly associated with behavioural variant frontotemporal dementia (40% of symptomatic cases) and heightened responsiveness with semantic dementia (73% of symptomatic cases) and Alzheimer's disease (78% of symptomatic cases).
The findings of Johnson et al. [ 66], Goujon et al. [ 67] and Carroll et al. [ 33] suggest that the increased expression of IFN-γ may be the result of a heightened immune responsiveness following weaning.
IFNα generated in response to self-RNA antigen is part of a positive feedback loop involving pDCs that supports increased TLR7 expression, thereby heightening responsiveness to self-RNA-containing immune complexes (Ganguly et al., 2009).
