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The phrase "a heavy setback when" is correct and usable in written English.
It can be used to describe a significant obstacle or difficulty that occurs at a specific time or under certain circumstances.
Example: "The project faced a heavy setback when the main developer left the team unexpectedly."
Alternatives: "a significant obstacle when" or "a major hindrance when".
Exact(2)
Tourism and trade, as well as hopes for a peaceful resolution to the country's 18-year-old ethnic conflict, suffered a heavy setback when Tamil rebels made a suicidal attack on the international airport on July 24, destroying a third of the national carrier's fleet.
Two days before the advance, the battalion suffered a heavy setback when their commanding officer, McSharry, was mortally wounded in a bombardment around Vaire, while trying to rescue a wounded soldier.
Similar(58)
Amid fears among senior Lib Dems that the party is heading for a heavy setback in next year's general election, the deputy prime minister made clear he had his sights firmly set on remaining in government when he predicted that Britain would experience further coalitions.
During one of these tests, AGS experienced a setback, when a dust explosion occurred.
Fortress dodged a major setback when it managed to refinance IntraWest, the big Canadian ski resort.
In August, Mr. Brownback suffered a setback when he finished a disappointing third in the Iowa straw poll despite heavy spending and vigorously attacking the eventual victor, Mitt Romney, as a flip-flopper.
The Redskins had a major setback when punt returner Richard Crawford injured his left knee.
The company suffered a major setback when it had to recall defective batteries in Fisker cars.
On Tuesday President Michel Martelly suffered a fresh setback when senators rejected his nominee for prime minister.
Watford suffered a further setback when Forestieri was shown a second yellow card for diving.
And Rovers suffered a further setback when midfielder Lee Williamson was carried off on a stretcher.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com