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The phrase "a handful of large" is correct and usable in written English.
It can be used when referring to a small number of large items or quantities, often to emphasize the limited nature of the selection.
Example: "In the garden, there are a handful of large pumpkins ready for harvest."
Alternatives: "a few large" or "several large".
Exact(59)
It can also shift policy conversations toward the idiosyncratic concerns of a handful of large donors.
Big investors continue to shop for bonds by placing calls to a handful of large dealers.
Back then, Aleppo's industry was dominated by a handful of large families.
The most desirable retail space is generally controlled by a handful of large property companies.
Most economic activity is concentrated in a handful of large cities and along the eastern coast.
Ms. Kaiser submitted the manuscript to editors at a handful of large New York publishing houses.
A handful of large private companies have mobilised quickly to take on contracts.
A handful of large aluminium processing plants absorb more than 70% of electricity generated in Iceland.
A handful of large business groups have been moving through systematically, buying up entire industries.
A handful of large road-transport companies compete with larger numbers of small haulers.
Similar(1)
We also own a handful of large-cap individual stocks that I have had for more than two decades.
More suggestions(16)
a handful of massive
a handful of enormous
a minority of large
a bunch of large
a number of large
a handful of wide
a handful of substantial
a pair of large
a handful of tremendous
a dozen of large
a series of large
a handful of vast
a couple of large
a multitude of large
a handful of sizeable
a handful of large scale
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com