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Due to its central role in mitosis, misregulation of Mps1 kinase activity results in chromosomal instability (CIN) and subsequent aneuploidy, a hallmark shared by cells from solid tumors [15], [16].
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Intracellular accumulations of altered, misfolded proteins in neuronal and other cells are pathological hallmarks shared by many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).
Furthermore, the RBV VP1 sequence revealed the conservation of the unique C-A-B motif arrangement in the palm subdomain of the RBV replicase, a hallmark that is shared by birnaviruses and the permutotetraviruses [ 33, 34].
As argued by Koonin and co-workers, viral hallmark genes shared by many groups of RNA and DNA viruses – but missing in cellular life forms – might be relics from the pre-cellular RNA/protein world [ 61].
It lies in the so-called Pr77-hallmark, a conserved region shared by retrotransposons belonging to the trypanosomatid L1 Tc/ ingi clade.
Evasion of programmed cell death (apoptosis) is a phenotypic hallmark that is shared by most human tumours (Hanahan and Weinberg, 2000).
It's a skepticism shared by many.
It's a philosophy shared by Mr. Horse.
It is a viewed shared by many.
It's a view shared by Zubrin.
It's a view shared by scientists.
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