Sentence examples for a guiding strand from inspiring English sources

Pre-miRNAs are then translocated to the cytoplasm where they are trimmed to remove the terminal loop and release ~22 nt long duplex mature miRNAs containing a guiding strand and a passenger strand.

One strand of the small dsRNA processed by Dicer, called a guide strand, is loaded onto an AGO protein to form RISC, which recognizes a target sequence that is usually embedded within the 3′ UTR region of a target mRNA in the P-body (Gregory et al., 2005; Liu et al., 2005; Eulalio et al., 2007).

It has been shown that in the RNAi machinery, the 3′-overhang region of a guide strand (an antisense strand) of siRNA is recognized by the PAZ domain in the Argonaute protein, and the 2-nucleotide (nt) 3′-overhang is accommodated into a binding pocket composed of hydrophobic amino acids in the PAZ domain.

There was an exception, as construct lhRNA rev-vif-tat e (Fig 4) was not able to generate a guide strand for the first position.

This mature miRNA consists of a guide strand and a passenger strand.

The miRNA-miRNA ∗ duplexes are made up by a "guide strand" and a "passenger strand" (miRNA ∗ ).

It binds a guide strand which helps it target complementary nucleic strands.

If this is true, then it is expected that the passenger strand of miR827 can function as a guide strand.

The siRNAs are double stranded molecules, consisting of a guide strand that is perfectly complementary to a target mRNA and a passenger strand.

The pre-miRNA is then cleaved by the RNase III enzyme Dicer and becomes mature miRNAs as a guide strand (miR) and a passenger strand (miR*) [ 32].

Recent crystal structures of Ago bound to a guide strand and its target RNA further highlighted the significance of the A-form helix in RISC catalysis.