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The phrase "a guide to define" is not correct in standard written English.
It can be used when referring to a resource or document that helps clarify or establish definitions for specific terms or concepts.
Example: "This book serves as a guide to define the key terms used in our research."
Alternatives: "a resource for defining" or "a manual to clarify".
Exact(3)
We use the benchmarks defined by Cordonnier et al. (2015) as a guide to define our set of benchmarks.
T2-weighted MR images are obtained for intraoperative tumor localization and act as a guide to define the treatment volume.
Recent studies utilize the RNA-guided endonuclease Cas9 from Streptococcus pyogenes and a guide RNA (gRNA), which acts as a guide to define the target site to introduce DNA double-stranded break.
Similar(57)
At that time the court was using a revised version of the Diagnostic and Statistical Manual IV, or the DSM IV-TR, as one of a few guides to define someone with intellectual disability: an IQ of approximately 70 or lower, with trouble learning or intellectually functioning since youth (the newest version of the DSM puts less emphasis on IQ, but still cites a measure of approximately 70 or below).
Participants were guided to define collectively what it meant for a household to be poor.
In five simple steps the engineer is guided to define the modularization goal, determine the required modularity, select the appropriate modularization method according to the initial situation and carry out the modularization task.
Add more guides to define cuts in the towers for ridges.
Usually that would make a lot of sense, but while Cervantes' professional history is intriguing and promising, especially to a new North American audience, it may not turn out to be all that defining as a guide to her future work.
By default, each mapped aesthetic defined inside aes produces a guide to aid interpretation of the graph: for positional aesthetics, the guide is a scaled axis, whereas for non-positional aesthetics, the default guide is typically a legend.
In fact, south of the border the dish is something of an embarrassment: a 1950s epicurean guide to Central America defined it as "a detestable food passing itself off as Mexican, sold in the US from Texas to New York".
Although this application and others with similar characteristics can be of interest in order to learn the position of the different regions of the brain by using an atlas, they do not serve as a guide as to how to define a specific region of interest.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com