In addition, the influence of clinical severity and of antiviral treatment on the extent and duration of viral shedding was evaluated in a group of hospitalized patients, for whom sequential NPS samples had been analysed.
The relationship between hypocalcemia and CIPNM was further explored by identifying a group of patients containing those most severely affected (Sequential Organ Failure Assessment score ≥9, n = 76).
The key advantage of a group sequential approach in which randomization probabilities are kept constant within sequential groups is that a stratified analysis will eliminate bias due to drift.
It was shown that the application of a group sequential design led to a maximal increase in sample size of 8% under the null hypothesis, compared with the fixed-sample design.
Statistical analysis was performed with use of a group sequential method, the triangular test (TT).
In each group of three sequential frames, the first is temporally compressed, the second is untouched, and the third is temporally stretched.
It is possible that manipulation of drug sequences may be of value when this type of combination is used and, accordingly, the French GERCOR group is undertaking a study of sequential docetaxel, cisplatin and epirubicin, the final results of which are awaited.
In the first series of analyses, the upper bound of a group-sequential 1-sided repeated CI for the HR must be ≤1.8 for registration in the United States.
