Exact(2)
In order to identify a group of pathways significantly enriched by DEGs in BC with respect to NS, we used a Pathway Enrichment Analysis from DEGS (PEA-DEGs).
Table 5 shows the model features, which include down-regulation of PAI-1 in a complex culture assay of bronchial epithelial cells and a group of pathways from databases such as GO, IPA, and KEGG.
Similar(57)
Biosynthesis of most amino acids can be seen as a hierarchy, in which a group of related pathways is associated with a specific precursor, often derived from the citric acid cycle or glycolysis intermediates [19].
We have identified a group of MAPK pathways related genes that are potentially synthetic lethal to p53.
A group of metabolic pathways P can be transformed to (i) the set of reactions in P; (ii) the set of enzymes that catalyse reactions in P; (iii) the set of genes whose products catalyse reactions in P; or (iv) the set of metabolites that are produced, or consumed, or both, by reactions in P. Transformations on chemical compounds.
For example, if a user is interested in a specific group of pathways using a lower cut-off like 40 combines them into the same cluster with very few other pathways, this cut-off would be appropriate.
A further group of pathways representing a number of disease-relevant gene expression signatures from human studies as defined by Chowdhary et. al.[ 41] were also queried.
The most dysregulated pathways included a group of key signalling pathways – such as p53 signalling, calcium signalling, MAPK, ErbB, vascular endothelial growth factor (VEGF) signalling and various cancer pathways.
Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations.
As expected from the overlap of differentially expressed genes in the knockout animal and the DDVP-exposed fish, a similar group of pathways is also enriched in the mouse knock-out experiment and in our study.
The pathway component stores a group of chains and pathways, which consist of a set of reactions.
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