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A depth-first search strategy was implemented to screen through all the SNVs and their associated reads to find Block of Mutations (BM), defined as a group of mutations where every mutation contains at least one read or read pair (either mutant or non-mutant) that is shared with at least one other mutation in that group (Fig. 2, A2).
The same A35T mutation is also present within a group of mutations that rescue a Flp variant, Flp Y60S), that is defective in establishing monomer monomer interactions on the native Flp target site.
However, when we have separated the mutations and generated new alleles that retain only some of them in a wt backbone, we failed to isolate a group of mutations that would be responsible for the toxicity.
Similarly, a group of mutations in breast cancer kataegis is characterized by a T CX motif signature.
Molecular analysis showed a group of mutations that have not yet been reported from Italy [ 3, 18].
There is a group of mutations that can be present in more than one unrelated patient (Table 2).
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3. Do the specific clusters of variants shown in figure 2 relate to specific mutation, or a group of specific mutations?
To understand better Frizzled receptor function, we have carried out a large-scale mutagenesis in Drosophila to isolate novel mutations in frizzled that affect planar polarity activity and have identified a group of missense mutations in cytosolic-facing regions of the Frizzled receptor that block Dishevelled recruitment.
The team conducted a series of experiments involving the gene for TIR3 and identified a group of 19 mutations that allowed the taste receptor to recognize sugars.
A group of rare mutations in MLH1 gene contribute to familial ovarian cancer [ 17].
The Tumor Sequencing Project (TSP) studied 188 lung adenocarcinomas and identified a group of somatic mutations that might affect the key pathways in adenocarcinoma development.
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