This groundbreaking observation opened a new era for T cell immunology, enabling description of antigen-specific T cells at a single cell level independently of functional properties.
By then, she'd spent more than 25 years in the field, completed her PhD, established the Gombe Stream Research Center, got married, raised a son and made further groundbreaking observations on chimpanzee society – including insights into chimp communication, sex, mother infant bonding, inter-community warfare and cannibalism.
The cloning of the gene responsible for CF pathophysiology, two groundbreaking observations made gene therapy for CF lung disease appear imminent.
A joint project between NASA and the ESA, SOHO was launched in late 1995 and has made groundbreaking observations of the sun's atmosphere and its roiling surface.
When Jane Goodall first went to Africa to study chimpanzees, she had no formal scientific training - but still managed to win the trust of the primates, leading to groundbreaking observations.
Over the next two decades, she made groundbreaking observations during her time among the mountain gorillas, including the first peaceful human-to-gorilla touch.
The concept of the placental role in brain development is relatively new and in line with the groundbreaking observations of fetal programming and disease susceptibility later in life (Barker 1990).
You would have thought that, when he published his observations in a groundbreaking series of reports in The Lancet, in 1867, his antiseptic method would have spread as rapidly as anesthesia.
Then a little later in a groundbreaking evening in Los Angeles – during which host Jimmy Kimmel issued constant tongue-in-cheek but pointed observations about increased diversity at the Emmys compared with the Oscars – came Paulson.
This systematic approach resulted in 1868 in a groundbreaking two-volume publication: "Photographic Views of Japan With Historical and Descriptive Notes, Compiled From Authentic Sources and Personal Observation During a Residence of Several Years".
