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The group controls only a sliver of territory in northern Afghanistan, and it suffered a grievous setback when its military leader was assassinated, just days before the attacks in the United States on Sept. 11.
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These "below-the-surface" relations suffered a grievous setback in 2010 when a Mossad hit team assassinated the Hamas operative Mahmoud al-Mabhouh in a Dubai hotel.
That he was subsequently ruled out of the Paris Saint-Germain tie on account of his weakened calf does not necessarily have to be a grievous setback for City, but it is a considerable one when their hopes of reaching a first Champions League semi-final depend to a great extent on the team's ability to defend coherently.
The announcement, and particularly its timing, certainly represents a grievous setback for the club bearing in mind their transformation since Pulis took charge when they were bottom of the division.
He had tried desperately to carry on and when he finally accepted it was futile it felt like a grievous setback to Portugal's hopes of denying France the outcome that would have meant so much in this city.
For Arsenal it would have been a grievous setback if they had allowed a side with these shortcomings to pinch a late equaliser.
Yes, their relegation in 2012 was a grievous setback and any club that struggles to get back under the parachute payments will inevitably suffer for it.
Thiago Silva and David Luiz had scored the goals to set up a semi-final against Germany in Belo Horizonte on Tuesday, but Neymar's injury represents a grievous setback given his importance to the team and the absence of a ready-made replacement.
Michael Carrick's own goal, after only eight minutes, might have been a grievous setback had United not swiftly set about demonstrating they can, once again, be regarded as a team of substance.
But there is little doubt Dudley's forced exit is a grievous setback for BP and a triumph for the troubled oil venture's Russian partners, who have been demanding his removal since May.
His absence was a grievous setback for Liverpool, who had looked the more dangerous team until that point, and it would not be sour grapes for the losers to think that was the moment the game started to swing away from them.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com