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This unpredictability is a greater problem when the treatment itself carries certain risks or deleterious side effects.
Toxicity is a greater problem when considering a two-hybrid system (or other expression library) of prokaryotic origin, since inappropriate expression of an E. coli gene is frequently a problem, particularly for genes encoding components of multisubunit complexes and transmembrane proteins.
The early flares occurred in association with the most intense serum urate-lowering effect in both febuxostat and allopurinol recipients, and early flares were a greater problem when prophylactic colchicine was stopped at 8 weeks as opposed to 6 months into urate-lowering treatment, but gout flares tapered off later in this study [ 38, 48].
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This can become a great problem, when API source, site of manufacturing, or manufacturing equipment is changed.
It is an even greater problem when synthetic association is not present.
This is an even greater problem when studying neurons or neuron-like cells derived from floating 'eurospheres'[2].
The lack of normative data, and well-validated instruments, is an even greater problem when assessing HRQL in adolescents and young adults [ 4, 5].
Just look at the tech companies and VC funds that distribute money to startups like those in media this year, and you'll see a similar – if not even greater – problem when it comes to women looking to get funded.
"There will be greater problems when the Americans leave," said Didar Abdulla al-Zibari, a member of the local provincial council.
Indeed, currently, the greatest problem when developing a serological assay is identifying, obtaining and preparing a suitable antigen.
"Teachers for my sister June and me were Mother's greatest problem when we were touring the country as a child vaudeville act".
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com