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The benefits of prostate cancer screening, he said, are "modest at best and with a greater downside than any other cancer we screen for".
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Even the "smart state" scenario, in which California leverages its technological prowess and invests in education to restart economic growth, has a big downside: greater income inequality.
"We went underweight equities last week because we see the maturing U.S. business cycle limiting earnings and price upside against greater downside risk from an eventual US recession," wrote JPM Chief Market Strategist Jan Loeys.
"With flexible capacity and diversification, we also see greater downside protection if traditional PC DRAM enters an extended downturn".
But John Walsh, acting head of the Office of the Comptroller of the Currency, who sits on the F.D.I.C. board and was the lone opposition vote, testified that the deadline could have been extended, and that "we didn't see any great downside" to doing so.
"I believe that the risks to the inflation outlook have become more balanced," he said, "given the greater downside risks to real growth".
"Uncertainty and challenges characterize 2008, with greater downside risk than real estate markets have faced in close to two decades," concluded the Emerging Trends in Real Estate report by PricewaterhouseCoopers and the Urban Land Institute, which interviewed more than 600 developers, services firms and investors over the summer.
There is little upside – and great downside – for a politician who can be plausibly cast as "weak" or a comfort to the enemy.
The greatest downside of industrialization is not exploitation of workers but toxic air and water.
For the Nets, the greatest downside of losing four straight games is losing the momentum and credibility built during a spectacular regular season.
The great downside of the revolutionary and progressive impact of warfare is the attempt by the state to make the citizen into state property.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com