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The phrase "a great weakness" is correct and usable in written English.
It can be used to describe a significant flaw or vulnerability in a person, system, or argument.
Example: "One of his greatest weaknesses is his inability to delegate tasks effectively."
Alternatives: "a major flaw" or "a significant shortcoming."
Exact(15)
Uncle Ratna had a great weakness for Pomegranates.
A great weakness of Israel is that Israelis believe so much of their own propaganda.
I do like being liked, which is a great weakness of mine".
The most glorious feature of American life is also a great weakness — a glamorous flaw.
"And having choices can either be a great strength or a great weakness".
As Sloan put it, "Mr. Durant was a great man with a great weakness — he could create but not administer".
Similar(41)
Analyses carried out on single layers of a-Si and a-Ge show that H is released from its bond to the host lattice atom and that it escapes from the layer much more efficiently in a-Ge than in a-Si because of the smaller binding energy of the H-Ge bond and probably of a greater weakness of the Ge lattice.
Therefore, in general, the new Dmd mdx/Large myd model had a worse performance in the bar for the front legs and four legs, when compared with the Large myd lineage, demonstrating a greater weakness.
At first, he thought of his decision as a defeat and a sign of great weakness.
It is pathetic and always a sign of great weakness.
Far from the confident days of Thomas H. Kean's two terms in the 1980's or Ms. Whitman's more tenuous two-term hold of the State House in the 1990's, Mr. Wilson has taken the reins at a time of great weakness for the state's Republicans.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com