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The phrase "a great vindication of" is correct and usable in written English.
It can be used when discussing a situation or event that justifies or proves the validity of a belief, action, or decision.
Example: "The recent findings were a great vindication of the scientist's controversial theory."
Alternatives: "a significant confirmation of" or "a strong justification for".
Exact(4)
"It is a great vindication of the great company that Sam and I put together," said Harlan W. Waksal, who helped his brother start and run ImClone.
It is hard to see how the transsition was anything but beneficial to the West, as well as to the Soviet Unionn, and sooner or later Geneva may be seen as a great vindication of General Marshall's hope that the problems we faced would, in time, change in ways advantageous to us.
It's also refreshing to have no fewer than 13 of the 15 come through our youth system, which is a great vindication of our under-age coaching structures.
"I'm delighted that Nigel Farage said that the result of the night was in Wales - and for us that's a great vindication of what we've done," said Mr Gill.
Similar(56)
"The evidence was overwhelming, and it's a great vindication for all of the women who have experienced what the 12 testifying women described".
"Tesla is repaying early and it's a great vindication," said Greg Kats, president of Capital-E, a firm that invests in clean-energy companies.
This is regarded as the great vindication of every young girl's fantasy – to get to be a queen by grovelling in a future king's bed!
VINDICATE Another Kindle-ready page-turner about women is one of the first: Mary Wollstonecraft's great "Vindication of the Rights of Woman," from 1792.
Origen's great vindication of Christianity against pagan attack, Contra Celsum, written (probably in 248) at Ambrose's request, survives in its entirety in one Vatican manuscript, with fragments in the Philocalia and on papyruses.
His most ethereal constellations of fantastic marks have the same authority as his earthiest landscapes: this is one of the great vindications of modern art.
A positive result will be a far greater vindication for Bush, whose campaign was declared dead in the water amid a series of stumbles last fall.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com