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The phrase "a great stumbling block" is correct and usable in written English.
It can be used to describe a significant obstacle or difficulty that hinders progress or success in a particular situation.
Example: "The lack of funding has become a great stumbling block for the project's development."
Alternatives: "a major obstacle" or "a significant barrier".
Exact(1)
That judgment was a great stumbling block for Hockney.
Similar(59)
Any political strategist would tell me that it's electoral suicide to speak so strongly and decisively against the "white moderates" that Martin Luther King Jr. castigated in his Letter from a Birmingham Jail as "the Negro's great stumbling block in his stride toward freedom".
The great stumbling block is the same as ever – Gordon Brown.
"I think that it has been public that one of the great stumbling blocks is that the House is not interested in funding the doctors and nurses and space that the VA needs," Sanders said.
A big stumbling block is cost.
This is a big stumbling block.
A big stumbling block remains.
Still, that cost reduction is a big stumbling block.
1. Sex can be a big stumbling block.
But Gould did not rule out sociobiological explanations for many aspects of animal behavior, and later wrote: "Sociobiologists have broadened their range of selective stories by invoking concepts of inclusive fitness and kin selection to solve (successfully I think) the vexatious problem of altruism previously the greatest stumbling block to a Darwinian theory of social behavior.
The perception among customers that what Hello Fresh offers is an alternative to shopping and not an occasional one-off treat is the greatest stumbling block, says Drake.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com