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The TT genotype of CYP1A2 polymorphism −1545C > T (rs2470890) was associated with a significantly greater side effect frequency during clozapine treatment as mean LUNSERS scores were 45.1, 36.8, and 37.9 in TT, TC, and CC carriers, respectively (p = 0.038), and 45.1 vs. 37.1 among TT carriers vs. TC or CC carriers (p = 0.011).
Axitinib appears to have a good tolerability profile, with hypertension being the most common grade 3 or greater side effect.
Bipolar patients who are currently depressed consistently endorse greater side effect burden than euthymic patients.
Furthermore, some drugs used in the chemotherapy as hydroxyurea, gemcitabine, taxanes have showed a radiosensitizing effect; however greater side effects can be found with these drugs.
Screening of MMPs specific inhibitors has gained attention recently but due to their monomodal nature, lack of specificity and greater side effects there is a need to develop therapeutic strategies focusing on prophylactic agents [ 45].
Moreover, if the doctor is unaware of the patient's non-adherence to oral therapy, he/she might attribute the disease progression to the ineffectiveness of the drug and change the regimen unnecessarily [ 10] or prescribe a second- or third-line medicine with greater side effects or costs.
Treatment resulted in greater side effects than had been predicted, and as a result many patients could not be considered for inclusion.
It is unknown if 4-OHT may exert 100-fold greater side effects if given at the same dose, but at a fraction of the dose that may be required to reach a therapeutic level, the side effects may not exceed those of tamoxifen.
