The phrase "a great modification of" is correct and usable in written English.
It can be used when discussing significant changes or alterations to something, often in a technical or academic context.
Example: "The researchers presented a great modification of the original theory, which improved its applicability in real-world scenarios."
Alternatives: "a significant change to" or "a major alteration of".
The individual gill septa are lost, and there is a great modification of the posterior branchial muscles, with many of the elements found in sharks (e.g., levators and adductors) becoming reduced or absent.
It is worth mentioning that, for all the values of L taken into account, settingα0 = 3L/4implies a great modification of the confining potential profile which, as one of the main features, presents a significantly reduced effective well depth.
Firstly, according to the structure activity relationship, drug combination principle and bioisosterism, the –COO– and the –NH– bond substituents at the 4 position of cycloparaffin would be a great modification direction to improve antitumor activity of 4′-demethylepipodophyllotoxin (DMEP).
It may be that the confusion with this particular concept requires greater modification of a student's cognitive framework, which would take longer for the student to process.
Thirty patients (8 females) with normal glucose tolerance and a clinical diagnosis of CKD stage 3 or greater (Modification of Diet in Renal Disease (MDRD) eGFR<60 mL min−1/m−2) (http://www.renal.org/CKDguide/full/UKCKDfull.pdf) were recruited from general nephrology clinics at the Royal Devon and Exeter Hospital.
The results showed high fat and sugar diets of processed food and confectionery were associated with greater modification of IGF2 in both sets of children.
At all four loci, there were strong trends towards greater modification of HOX genes located at the 5′ end of each of these loci.
Except for the nautilus, all living members of the class show great modification and reduction of the characteristic molluscan shell.
Considering these characteristics, there is a great chance of modification and polymer formation during the preparation processes of albumin products, especially injections.
Furthermore the system architecture of GPUs may not be suitable for the MapReduce architecture and may require a great deal of modification [ 9].
Subsequent to the first report in the 1940s on incubation of tissue sections with fluorescein-conjugated antibodies for localization of antigens, a great number of modifications were introduced to improve the validity of immunohistochemistry which has become a growingly popular tool.
