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The phrase "a great effect on" is correct and usable in written English.
It can be used when discussing the influence or impact that something has on another thing or situation.
Example: "The new policy had a great effect on employee morale and productivity."
Alternatives: "a significant impact on" or "a profound influence on".
Exact(56)
It is noted that fiber packing configuration plays a great effect on the effective elasticity.
It had a great effect on me.
"Woody had a great effect on my life," he said.
He had a great effect on the team room too.
Local topography also has a great effect on Beijing's climate.
It had a great image in Syria — it had a great effect on all of us".
He was so engaging, though – he really had a great effect on set.
Still, he acknowledged that his family's history has had a great effect on him.
Behavioral patterns of host populations often have a great effect on the transmission of infectious agents.
Similar(2)
It is well known that diseases have a great effect on people's health.
Ni/γ-Al2O3 catalyst had a great effect on the CO selectivity and CO2 conversion.
More suggestions(21)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com