The phrase "a great difficulty to" is correct and usable in written English.
It can be used when describing a challenging situation or task that someone is facing.
Example: "It was a great difficulty to complete the project on time due to unforeseen circumstances."
Alternatives: "a significant challenge to" or "a considerable obstacle to".
Complex interface distribution brings a great difficulty to the fracture analysis of MEE materials since the present fracture mechanics methods can hardly solve the fracture parameters efficiently of a crack surrounded by complex interfaces.
A great difficulty to attack this class of problems is how to discretize the space of convex functions.
As we mentioned before, the change of sign of f brings a great difficulty to the solvability of (1.1), so in this paper, we only consider the nonnegative case.
Since these numerical models are formulated based on different assumption and theories, the models accuracy, computing time, and applicability vary, which poses a great difficulty to practicing engineering and limits their confidence in the analysis resultants.
However, these PLs showed a great difficulty to realize the focusing beyond the diffraction limit, until the dispersion relation of the metal-insulator-metal (MIM) waveguide was employed for the nanoslit-based PLs to modulate the phase at the subwavelength scale [11, 15 17].
Although a large amount of diverse biological data and results have been reported in the previous germination studies, it faces a great difficulty to compare or integrate those data because the developmental stages of the germinating tissues used in most of those studies are not well defined.
Other authors [ 14] found not only a greater difficulty to maintain the set but also more perseverative errors in obese with BED than in obese controls; this last result should be better addressed comparing BED obese patients with AN and normal-weight HC in order to ascertain if this is a real or a relative increment of perseverative errors.
It is indeed a matter of great difficulty to discover [cognoscere], and effectually to distinguish [actu discriminare], the true motions of particular bodies from the apparent; because the parts of that immovable space, in which those motions are performed, do by no means come under the observation of our senses [incurrent in sensus].
"This is really about a company trying with great difficulty to navigate the byzantine maze of politics in Yonkers," he said.
He managed, with great difficulty, to extract a three-month ceasefire from Hamas, Islamic Jihad, and the al-Aqsa Brigades that are linked to his own Fatah movement.
Wasson managed with great difficulty to find a curandera who allowed him to ingest the mushrooms as part of a sacred ceremony.
