The phrase "a great cause of" is correct and usable in written English.
It can be used to indicate a significant reason or factor contributing to a particular situation or outcome.
Example: "The lack of funding was a great cause of the project's failure."
Alternatives: "a major factor in" or "a significant reason for".
Having a passenger drop his seat backwards into another passenger's space is a great cause of angst.
It was a great cause of envy for my friends, though we had only one film, 'The Fabulous Señorita,' which we watched over and over again".
We could sell tickets for the March of Dimes, a great cause of his; Rob would be tough no matter what the game was.
Yesterday the environment minister Michael Meacher said the collapse of the Larsen B shelf was "a great cause of concern and a wake-up signal to the whole world".
"It is a great cause of anxiety when an older sibling develops autism.
But the prime minister told BBC Radio 4's Today programme that Europe had been a "great cause of unity" among Tories attending their annual conference in Birmingham.
"In the U.S., flooding is a greater cause of death than lightning or tornadoes, and presumably poses similar risks elsewhere".
Sugary drinks, addiction and obesity are inextricably linked: excess sugar in the diet may be a greater cause of obesity than fat is.
Detritus from nuclear commerce that has slipped through American and international regulatory systems is another periodic source of alarms, and one that has proved to be a greater cause of concern.
Other historians, however, argue that a greater cause of salutary neglect was not deliberate but was instead the incompetence, weakness, and self-interest of poorly qualified colonial officials who were patronage appointees of Walpole.
It has become proportionally a greater cause of major maternal morbidity and mortality as the frequency of other serious obstetric complications has declined.
