The phrase "a grave setback in" is correct and usable in written English.
It can be used to describe a significant obstacle or difficulty encountered in a process, project, or situation.
Example: "The unexpected loss of funding was a grave setback in the development of the new technology."
Alternatives: "a serious obstacle in" or "a major hindrance to".
MOSCOW — The Russian government said Wednesday that it would not renew a hugely successful 20-year partnership with the United States to safeguard and dismantle nuclear and chemical weapons in the former Soviet Union when the program expires next spring, a potentially grave setback in the already fraying relationship between the former cold war enemies.
The triumph of democracy and tolerance in Iraq, in Afghanistan and beyond would be a grave setback for international terrorism.
A wild stock rally followed by a crash, as happened in 2006-07, would be a grave setback.Since looser monetary policy is the right medicine for the economy but a risk for overheated shares, the solution could be stricter regulation of the stockmarket itself.
But the settlement of October 1465 was a grave setback for the king, whose brother Charles gained title to Normandy while Charles the Bold, soon to inherit Burgundy, acquired strategic counties and towns in Artois.
Turkey's democracy is still an experiment, still fragile and still at risk of a grave setback.
Losing him because of this would be a grave setback and I hope it will be unnecessary.
The outcome seems a grave setback to hopes for a solution to the looming international crisis over Iran's nuclear ambitions and for détente with the US in response to Barack Obama's overtures.
"What has happened is a grave setback to the process of normalisation of relations and the confidence-building measures with Pakistan," he told the AFP news agency.
France could scarcely afford to its security was too tightly bound to Russia's but France's policy of wooing Italy out of the Triple Alliance was a grave setback, not for Germany but for Austria-Hungary.
This week it had another grave setback, as American regulators announced a ban on imports from a new factory that was supposed to solve Ranbaxy's quality problems.In May the company hoped to put its troubles behind it, by agreeing to a $500m settlement with the US Department of Justice.
