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Calculation data also show that cyclopentadithiophene although is a good moiety for extending the conjugation length of the organic dyes, it also acts as an electron sink, decreasing the effective electron injection.
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As shown the BTP is a good electron-accepting moiety for electronic materials due to the presence of the three electron negative heteroatoms.
The DTP moiety is a good candidate for the design of BTZ-based sensitizers used in DSSCs.
In particular, the three-dimensional model of GPER was successfully tested as a protein target, and docking simulations run in silico demonstrated a good affinity of the agonist moiety G-1 for the receptor (Lappano et al., 2010), in accordance with previous data (Bologa et al., 2006).
Experimental results proved this novel BODIPY compound with the benzimidazole moiety to be a good candidate for pH probe applications.
Therefore, the compounds containing 1,3,4-oxadiazole moiety may be a good choice for optical material or biologically active chemicals [ 7].
Then, the electrochemical properties of FecNCD2 were evaluated and were found to show a good redox response due to the ferrocene moiety.
A histidine residue protonates the sulfate moiety, transforming it into a good leaving group (Knaus et al. 2012).
The conjugate addition between thiols and the maleimide moiety is a routine reaction, and a good yield of coupling was confirmed by the absence of any reduced sulfhydryl group on the freshly purified bioconjugate (Ellman), so the product was used as eluted from the column.
Therefore, a good balance between lipophilicity and functional groups within the molecular moiety is a key when designing biologically active imaging agents.
Thus, analogs 3a 3f without sulfonamide moiety were synthesized and biological assay revealed a good activity as well as an excellent selectivity as inhibitors for tumor associated hCA IX and hCA XII and the same was analyzed by molecular docking studies.
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