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For all the exposure times, a good dose response was observed between 0 and 2 Gy and also between 2 and 4 Gy for most of the genes.
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A good dose-response relationship was obtained between intermittent noise and subjective sleep quality: i.e., the higher the noise level, the poorer the sleep quality.
Additionally, a good dose-response relationship between EXCH-Pb content and respiration intensity might provide a basis for ecological risk assessment.
A good dose-response correlation could be detected for compound 109, with a 4- to 9-fold upregulation of frataxin mRNA at the highest tested concentration of 10 µM.
In conclusion, all spiroindolone analogs studied displayed a good dose-response relationship in the P. berghei murine model.
The SENCAR mouse model provides a good dose-response relationship for many carcinogens used as tumor initiators and for many compounds used as tumor promoter.
In vivo examination of 22 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose dependent response with maximal reduction in glucose level reached at 50 mg/kg.
Author response: Indeed, a good dose of both skepticism and careful thinking are very much needed.
While there have been several studies showing that arsenic exposure affects liver function, good dose-response data are not available.
Primary depression and depression secondary to medical conditions show good dose-response reactions to medication, which is less clear in the case of depression secondary to stress.
Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points.
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