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At the same time, the science of stratigraphy was in its infancy, and the primary focus of its earliest practitioners was to use the newly discovered sequential progression of fossils in layered sedimentary rocks to establish a global sequence of temporally ordered stages.
These categorical roles are assigned as a function of a panel's semantic content (i.e., the meaningful cues depicted in the image) and its context in a global sequence (Cohn, 2013b, 2014b).
The top four FASTA hits (Figure 4A) were aligned with the intact or deleted arms using a global sequence alignment method (NEEDLE).
The helix-turn-helix is a common motif and without a global sequence similarity, an evolutionary lineage based solely on active site similarity cannot be readily established.
In an attempt to identify novel residues required for recognition and palmitoylation of protein substrates, we performed a global sequence alignment of MBOAT family members with known protein substrates – Hhat, Porc and GOAT.
For example, a recently published analysis of sequence polymorphisms in ST5 (a global sequence type belonging to agr group II) suggests a higher degree of diversity in Europe, and an expansion approximately 1,000 years ago [21].
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Along a different vein, we have a commentary promoting the development of a digital immune system to serve as a global sequencing based pathogen monitoring system as increasing sensitivity and decreasing costs of sequencing technologies increase utility of sequencing as a sensor [ 7].
The finished de novo assemblies were subjected to an initial round of redundancy reduction using CD-HIT-EST v3.1, clustering with a 5% global sequence similarity threshold, as a heuristic means of clustering transcripts expressed from the same putative locus but not clustered into the same subcomponent by Trinity.
Quantification of assemblies was done using Vmatch for large-scale sequence matching (a large-scale global sequence alignment)[ 35].
It has been suggested that differential amplification of mobile elements may change in a short time the global sequence pattern of a chromosome, especially if the elements have simple internal sequences that contribute to the generation of new microsatellites [ 64].
Transcriptomic comparisons also showed a high level of global sequence conservation between these two species.
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