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Discover LudwigThe phrase "a global decrease in expression of" is correct and usable in written English.
It can be used in scientific or academic contexts when discussing a reduction in the levels of expression of a particular gene, protein, or other biological factors across a wide range of subjects or conditions.
Example: "The study revealed a global decrease in expression of the target gene in response to the treatment."
Alternatives: "a widespread reduction in expression of" or "a universal decline in expression of".
Exact(1)
One prediction that follows from decreased expression of Tfam would be a global decrease in expression of mitochondrial encoded protein subunits of the ETC in SOD2 deficient cells.
Similar(59)
However in contrast, GC15 shows a global decrease in expression.
The last interval, between 40 to 60 DAA, included 49% of all significant changes detected, and was characterized predominantly by a global decrease in gene expression.
These observations, although limited to an incomplete sample of the whole genome, are consistent with the idea that a global decrease in gene expression is expected to result in a decrease in translation.
A global decrease in miRNA expression has been observed in human cancers, suggesting that most miRNAs may act as tumor suppressors [ 27].
In contrast, we [ 10] (and others [ 28]) recently demonstrated that T-cell malignancies are associated with a global decrease in microRNA expression.
The reduced PABCP levels by genistein may also indicate a global decrease in mRNA translation that may account for the reduced expression of all of the proteins that were tested.
Hypoxia decreases global gene expression via epigenetic pathways: A global decrease in H3K9 acetylation can be observed in various types of cells as a consequence of increased HDAC activity [ 76, 77].
Expression of DrAqp3b-H53A or -G54H (Additional file 2) in oocytes led to a global decrease in water permeability with respect DrAqp3b-WT oocytes and did not affect pH sensitivity.
The survey of resistance showed a global decrease in 2006 versus 2005.
Our study in an animal model found that influenza infection leads to an increase in the expression of muscle-degrading genes and a decrease in expression of muscle-building genes in skeletal muscles in the legs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com