Sentence examples for a given variant of from inspiring English sources

Having calculated the equivalent stress and the rate of equivalent creep strain, the condition of fuel rod cladding failure used on the basis of the energy version of the theory of creep gives us a criterion to decide if a multiple cyclic power change operating mode is permissible for a given variant of power history and coolant conditions.

Using in silico models, namely PolyPhen-2 (Polymorphism Phenotyping v2), SIFT (Sorting Intolerant From Tolerant), and LOFTEE (Loss-Of-Function Transcript Effect Estimator), ExAC estimates the impact of a given variant on protein function.

A combination of terms from the two ontologies is used to specify the characteristic of a normal protein (GO) and the effect of a given variant on it (VariO).

The potential effect of a given variant on structure stability within rRNA and tRNA genes (free energy, Δ G) was assessed using the RNAeval application of the Vienna RNA Package (version 1.8.5, www.tbi.univie.ac.at/RNA/, last accessed April 22 , 2013.

The possible effect of a given variant on exonic splicing enhancers was assessed using the ESEfinder 3.0 program [ 23] and on splice consensus sites using NNSPLICE [ 24] and Splice Site Finder [ 25] web based programs.

Although CRISPR/Cas9 can be utilized to demonstrate the functional impact of a given variant, the complex phenotypes of many diseases are not easily modeled in vitro and thus the determination of causality will often not be trivial.

Since nHS can only calculate a z-score for the least frequent allele of a given variant, it was only used when the allele of interest had a frequency <0.5.

Also, an option to explore the presence or absence of a given variant in affected/unaffected family members (based on simultaneous comparison of their encrypted genomes) could allow for adjusting the weight assigned to different variants and further improve PhenoVar's efficiency.

This would allow the evaluation of the post-translational consequences of a given variant.

The prediction of the phenotypic risks and putative functional effects of a given variant in the regulatory region were assessed using function analysis and selection tool for single nucleotide polymorphism (FASTSNP) [ 32].

We demonstrate the existence of a striking negative correlation between the aggregation propensity of a given variant and the oxidative stress it elicits.