The phrase "a given trinucleotide sequence" is correct and usable in written English.
You can use it in contexts related to genetics, molecular biology, or bioinformatics when referring to a specific sequence of three nucleotides.
Example: "In our study, we focused on a given trinucleotide sequence that is known to be associated with a particular genetic disorder."
Alternatives: "a specific trinucleotide sequence" or "a particular trinucleotide sequence".
The Markov chain method assumes that tetranucleotide frequencies have the same likelihood of occurrence, given trinucleotide frequencies, as trinucleotide frequencies have, given dinucleotide frequencies.
Interrogating the bases either side of each substitution to give a trinucleotide sequence context comprising 96 possible combinations followed by non-negative matrix factorization, the authors were able to decompose the spectrum of sequence contexts into five signatures ('signatures A-eacheach believed to represent the scar of a distinct mutational process [ 1].
Our measure of compositional bias simultaneously considered all 64 trinucleotides across a given sequence using a multivariate statistical technique (Correspondence Analysis, see Methods).
An implication of this particular point is that the frequencies of trinucleotides taken over sufficiently large regions are better predictors than GC of the isochore family to which a given sequence belongs.
For each di- or trinucleotide at a given position in the consensus sequence of an alignment, the mutation frequency was computed as the number of sequence fragments with a transition mutation at that position divided by the total number of aligned sequences.
The disorder is caused by dynamic mutation of a single trinucleotide sequence, CGG, on the X chromosome.
One example is Huntington's disease (HD), which is caused by a genetic mutation where a specific trinucleotide sequence is repeated a variable number of times, and persons with a number of these repeated trinucleotides over a certain threshold will develop HD.
After calculating the oligonucleotide frequencies of all sequences, the minimum and the maximum frequency of a particular di-or trinucleotide in a given species were calculated.
The origin of DM is an expansion of the trinucleotide sequence CTG in the 3'-untranslated region (UTR) of the DMPK gene.
For instance, the pressure for 3rd-position GC is simply the sum of a given group's average preferences for the trinucleotide motifs ending in CorG, minus that of the preferences for the trinucleotides ending in TorA.
