In toxin-induced models, LID already appears after a couple of days and stabilize at a given score, whereas in PD patients LID develops slowly and increases in severity and duration with time (Fox & Brotchie 2010).
The complete list of components, each with their criteria justifying a given score, is displayed in the Additional file 1.
The resulting q-value defines the fraction of tolerated false positives above a given score arising by random chance in our background model.
Importantly, these anchor-based methods have the advantage of linking the change in a given score to the patient's perspective (which is captured by the anchor) [ 23].
More importantly, ratings assume utility to be a cardinal construct such that a given score measures the same utility across individuals and a given difference in score is associated with the same difference in utility under all circumstances.
All of the profiles that do not meet a certain threshold (in terms of a given scoring function) are eliminated in this phase.
The genome-wide adjusted P-value is the proportion of this ordered list that is greater than or equal to a given LOD score in the original QTL map.
Moreover, some authors proposed that the presence of a given focal score in MSGs could be the mandatory criterion to classify a patient as having SS [ 5].
Secondly, the ordinal nature of summated scores implies that a given difference in scores at one point on the scale does not necessarily represent the same amount of functional change as an identical difference at another point on the scale.
Each predictor corresponds to a given risk score (the coefficient in the logistic regression multiplied by 25).
