Sentence examples for a given pathway in from inspiring English sources

The predicted miRNA target genes were analyzed for enriched KEGG pathways by using the NCBI DAVID server (http://david.abcc.ncifcrf.gov) with default setting, in which the null hypothesis is that no difference exists between the number of genes falling into a given pathway in the target gene list and the genome as a whole [33].

One question addressed here was which signatures could be considered relevant to human cancers of a different cell type from breast, in other words, whether genes associated with a given pathway in an experimental model show patterns of expression in human tumors that would be consistent with that pathway association.

A Boolean matrix with pathways in rows and datasets in columns was generated, where matrix cells equal to 1 identified significant enrichment of a given pathway in a given dataset, and 0 otherwise [ 21, 22].

In examining the neuregulin pathway, we observe the variability among samples in the mechanism of dysregulation of this commonly altered breast cancer pathway, highlighting the importance of multi-dimensional analysis of a given pathway in individual tumor samples -- in addition to the conventional approach of identifying loci simply based on frequency of disruption in a cohort.

This hole-filling is an iterative process, since introduction of new reactions into the network might justify the introduction of yet new pathways in the model, depending on the manually set cut-off for presence of a given pathway in the model.

For a given pathway in a particular organism, we fixed the total number of protein-coding genes in this organism (N), the number of genes involving this pathway (N1), the number of total bidirectional genes in this organism (N2), and treated the number of bidirectional genes in this pathway as a random variable.

Theoretically, certain control points may play an especially critical role in a given pathway, i.e., they may be "determining events".

These include similar expression patterns, common functions in a given pathway, participation in a metabolic channelling event or collaboration in a specific cellular process.

The difficulty in measuring all the components of a given pathway results in following simple rules of thumb based on the minimal number of elements sufficient for a pathway to be considered as present.

Finally, observing the same gene in a given pathway being deregulated in a completely different manner between samples highlights one of the shortcomings of group-based analysis and highlights the eventual need to move to systems analysis of tumors as individual entities.

Moreover, it is possible to perform epistasis experiments using combinations of dominant and recessive mutations (or mutants with opposing phenotypes) in a given pathway to determine the sequence in which genes act in that pathway.