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To take a simple case: if there are three possible combinations of alleles at a given locus in a population, we can characterize the outcome of a reproductive cycle as 'chance' if each of the three possible combinations occurs at a frequency determined strictly by the laws of probability.
The rare or infrequent deletions we tabulated were scattered across the genome, and by definition occur at a given locus in less than 5% of our sample (that is, 9 of 196 individuals).
The He represents the probability of finding a different allele for a given locus in any pair of haploids randomly drawn from the same population, and it was computed with FSTAT version 2.9.3 [16].
Using novel 4C technology, which allows for an unbiased genome-wide search for DNA loci that contact a given locus in the nuclear space, we recently demonstrated that the active β-globin locus in fetal liver contacts transcribed loci whereas the inactive β-globin locus in fetal brain contacts transcriptional silent loci elsewhere on the chromosome [15].
Genetic variation at a given locus in a population is measured by the observed heterozygosity (HO).
However, the presence of a given locus in a genome is not a guarantee of its expression.
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First, we did not observe any repeated amplification failure for any given locus in any population (which is expected with null alleles since homozygotes for a null allele will produce no PCR amplification).
Heterogeneity is also present in terms of the strength of effect found at any given locus in the three STRUCTURE groups, where both INRA111 and BMS2753 show strong associations in one group but substantially weaker trends in the other two.
At any given locus in the genome, the accessible face can be random among individual cells (that is, variable rotational positioning) or, in the other extreme, a particular face can be consistently accessible in all cells (that is, exhibiting a constrained rotational positioning).
Deep unbiased exome sequencing will also allow for burden test analyses of the combined impact on phenotype of multiple rare and low-frequency variants in a given locus or in other functional units such as a biologically relevant pathway [ 32].
In only one case did all species in a subsection exhibit a null allele for a given locus (Sg_7 in subsect. Squarrosae).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com