Model comparisons were based on multiple indicators while recognizing that specificity at a given level of sensitivity is a key discriminating factor.
The model described here serves as a novel tool for protein annotation by predicting the specificity of function, based on the GO hierarchy, which may be shared between two proteins for a given level of sequence similarity.
These parameters can be global (i.e. temperature) or local to a given level (kinetics, substrate specificity, etc).
Since crossing over of ROC curves may affect the diagnostic properties of a variable without changing the AUC, we also ranked the variables based on sensitivity levels by adapting the cut-off to a given preset specificity level of 95% [ 16].
However, at a given specificity level, sensitivity of any double FIT sampling strategy for SRN is comparable to single FIT sampling at a different cut-off value.
It therefore appears that shearwater achieves a good level of specificity, given that Caveman used a series of post-processing filters, whereas deepSNV and MuTect did not.
Bankstocks.com also says the e-mail messages it gets, because they are usually from people in the industry, generally have a level of specificity one does not find on a message board.
The specificity advantage of the SBM method can be expected to be partly independent of the threshold, since moderate relaxation of the threshold for a classifier that attains a high level of specificity with a given threshold can be assumed to retain some of the specificity advantage.
Given their high level of specificity, ANCA detection is critical for AAV diagnosis, and ANCA positivity with a compatible clinical diagnosis usually allows the initiation of immunosuppressive treatments [8, 9].
Information in each category must reach a certain level of specificity.
